Is abnormal adrenergic activation associated with abnormal Heart Rate Recovery?

نویسندگان

  • Leandro Rocha Messias
  • Maria Angela M de Queiroz Carreira
  • Sandra Marina Miranda
  • Jader Cunha de Azevedo
  • Isabela Ambrósio Gava
  • Ronaldo Campos Rodrigues
  • Elisabeth Maróstica
  • Claudio Tinoco Mesquita
چکیده

BACKGROUND Heart Rate Recovery (HRR) reflects the capacity of the cardiovascular system to reverse the vagal withdrawal caused by exercise. Scintigraphy with metaiodobenzylguanidine (I(123) MIBG) evaluates innervation and cardiac adrenergic activation. The association of these two methods is not well established. OBJECTIVE To evaluate the association between HRR and washout rate (WO) of I(123) MIBG in patients with heart failure (HF). METHODS Twenty-five patients with ejection fraction < 45% underwent exercise testing, and analysis of the variation of HRR from the 1st to the 8th minute after exertion. Submitted to I(123) MIBG, they were separated into groups by WO: G1) <27% and G2) ≥ 27%. For the statistical analysis Mann-Whitney's U test and Spearman's correlation coefficient were used. RESULTS G2 showed a slower variation of HRR: 1st minute: G1: 21.5 (16.12 to 26.87) vs. G2: 11.00 (8.5 to 13.5) bpm, p = 0.001; 2nd minute: G1: 34 (29-39) vs. G2: 20 (14 - 26) bpm, p = 0.001; 3rd minute: G1: 46 (37.8 - 54.1) vs. G2: 30 (22 - 38) bpm, p = 0.005; 5th minute: G1: 51.5 (42 - 61) vs. G2: 39 (31.5 to 46.5) bpm, p = 0.013, and in the 8th minute: G1: 54.5 (46.5 - 62.5) vs. G2: 43 (34 - 52) bpm, p = 0.037. HRR in the 1st (r = -0.555, p = 0.004), and in the 2nd minute (r = -0.550, p = 0.004) were negatively correlated with WO. CONCLUSION Patients with high HF and WO showed an abnormal HRR compared with patients with normal WO. These findings suggest that adrenergic activation may influence the HRR.

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عنوان ژورنال:
  • Arquivos brasileiros de cardiologia

دوره 98 5  شماره 

صفحات  -

تاریخ انتشار 2012